The government needs development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins, as part of DARPA's Protein ENGineering (PENG) program.
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We are seeking quotes for development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins, as part of DARPA's Protein ENGineering (PENG) program.
Program goal: Move proteome engineering from isolated, bespoke tools to a universal, software-defined discipline.
Platform components: An integrated platform of modular targeting, generalizable effector chemistries, and multiplexed control systems.
Technical approach: Integrate novel splicing, ligation, and co-translational techniques to recognize, modify, and rewrite endogenous proteins in complex biological systems.
Development path: Performers may explore multiple technical paths, advancing from foundational validation to robust demonstrations of efficacy.
Final validation: Validate the integrated platform in high-fidelity cellular models, such as organoids, as tissue-level proof-of-concept.
The basics
Price due
October 19, 2026
Buyer
Department of Defense, Def Advanced Research Projects Agcy
We read the solicitation documents for this bid (8 documents, 88 pages). Each item shows the file and page it came from. Check the original documents and any addenda before you bid.
Due date and time
Proposal abstract is due August 24, 2026, at 4:00 p.m. ET. (Attachment 8, p. 2)
Tentative full proposal due date is October 19, 2026, at 4:00 p.m. ET. (Attachment 8, p. 2)
Pre-bid meeting or site visit
Proposers Day is August 10, 2026 (all times Eastern Time). (Attachment 8, p. 2)
Questions deadline
Question submittal closed August 17, 2026, at 4:00 p.m. ET. (Attachment 8, p. 2)
Contract term
Period of performance is eighteen months for Phase 1A, six months for Phase 1B, and eighteen months for Phase 2. (Attachment 8, p. 2)
Scope highlights
Protein ENGineering (PENG) program under DARPA Defense Sciences Office, to be awarded as Other Transaction Agreements for Prototype. (Attachment 8, p. 2)
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Recent comparable awards for similar work — not necessarily this exact solicitation's history.
Want to bid it yourself?
You can, and it is free. Go to SAM.gov, search for solicitation DARPA-PS-26-129, and submit before October 19, 2026. You will need your own account on that site and an active SAM.gov registration.
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