The government needs a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins under DARPA's Protein ENGineering (PENG) program.
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We are seeking quotes for a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins under DARPA's Protein ENGineering (PENG) program.
Program scope: Build an integrated platform of modular targeting, generalizable effector chemistries, and multiplexed control systems.
Core techniques: Integrate novel splicing, ligation, and co-translational techniques to recognize, modify, and rewrite endogenous proteins.
Approach: Platform must be target-agnostic rather than a collection of isolated, target-specific tools.
Phased progress: Performers may explore multiple technical paths, advancing from foundational validation to robust demonstrations of efficacy.
Final validation: Validate the integrated platform in high-fidelity cellular models, such as organoids, as a tissue-level proof-of-concept.
The basics
Price due
October 19, 2026
Buyer
Department of Defense, Def Advanced Research Projects Agcy
We read the solicitation documents for this bid (10 documents, 113 pages). Each item shows the file and page it came from. Check the original documents and any addenda before you bid.
Due date and time
Tentative proposal due date is October 19, 2026, at 4:00 p.m. Eastern Time. The proposal abstract was due August 24, 2026, at 4:00 p.m. ET. (Attachment 6, p. 2)
Pre-bid meeting or site visit
Proposers Day was held August 10, 2026 (Eastern Time). (Attachment 6, p. 2)
Questions deadline
Question submittal closed August 17, 2026, at 4:00 p.m. Eastern Time. (Attachment 6, p. 2)
Licenses and certifications
All proposers must submit the DARPA-specific representations and certifications for Prototype OT awards (Attachment G) to be eligible for an OT award. (Attachment 6, p. 14)
Set-aside and participation goals
Cover sheet must state organization type: Large Business, Small Disadvantaged Business, Other Small Business, HBCU, MI, Other Educational, or Other Nonprofit. (Attachment 4, p. 2)
Contract term
Period of performance is eighteen months for Phase 1A, six months for Phase 1B, and eighteen months for Phase 2. (Attachment 6, p. 2)
Pricing format
Cost proposals must use Attachment F: DARPA Cost Proposal Spreadsheet, in editable format with formulas intact, and cover Phase 1A, Phase 1B and Phase 2. (Attachment 4, p. 1)
Forms to return
Return the Attachment F cost proposal spreadsheet and the Volume II cost proposal with the cover sheet. (Attachment 4, p. 1)
Scope highlights
DARPA Protein ENGineering (PENG) program, Defense Sciences Office, with multiple Other Transaction Agreements for Prototype anticipated. (Attachment 6, p. 2)
Phase 1A (Base), Platform Foundations: establish foundational biochemistry of the editing platform and demonstrate target generalizability over 18 months. (Attachment 6, p. 5)
National Aeronautics and Space Administration — $585,000 — October 31, 2028
National Aeronautics and Space Administration — $580,000 — October 13, 2026
Department of Veterans Affairs — $112,800 — October 1, 2026
Department of Veterans Affairs — $45,400 — October 1, 2026
Department of the Interior — $939,084 — October 1, 2026
Recent comparable awards for similar work — not necessarily this exact solicitation's history.
Want to bid it yourself?
You can, and it is free. Go to SAM.gov, search for solicitation DARPA-PS-26-129, and submit before October 19, 2026. You will need your own account on that site and an active SAM.gov registration.
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